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Re: DewDiligence post# 244135

Thursday, 10/13/2022 10:54:14 AM

Thursday, October 13, 2022 10:54:14 AM

Post# of 257484

however, on efficacy against severe LRTI, GSK’s 94% and PFE 86% are well within the confidence intervals of both point estimates



the more relevant comparison is the 66.7% vs 94.1% endpoint

both of these endpoints were defined similarly.

PFE: protection against RSV-associated lower respiratory tract illness (LRTI-RSV) defined by two or more symptoms demonstrated vaccine efficacy: 66.7%

GSK Efficacy against severe RSV-LRTD, defined as LRTD with at least two lower respiratory signs or assessed as severe by the investigator and confirmed by the external adjudication committee, was 94.1%

This is most apples to apples comparison here
yes in a week or so both will present the data and we will know more
the market agrees w you but I think is missing the fact that severe dx in gsk more or less = milder dx in PFE (in fact GSK definition is more permissive w a 2+ symptoms OR subjective assessment a severe by investigatorss)

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