Innovation Pharmaceuticals Inc (IPIX)

[olden_grumpini]

Factoring in the difference between mouse and human, the 50 mg/kg mouse dose converts to a 4 mg/kg human dose. This is not nearly as bad as I first thought (and probably not toxic) but still more than 3X the highest dose IPIX used in their P2 ABSSSI study.

To give you an example of what would be a toxic dose, the GMU paper in viruses calculated brilacidin’s CC50 (the concentration at which 50% of the Calu-3 cells are no longer viable) to be a concentration of 241 µM. That works out to be a dose of 19 mg/kg (see below for how to convert brilacidin from µM to mg/kg). Calu-3 cells are human airway epithelial cells.

There were a number of instances in the paper where brilacidin at lower concentrations combined with CAS had an effect (Cryptococcus neoformans, Candida albicans, and Candida auris for example).

Converting brilacidin from µM to mg/kg
IPIX provided the means to do a conversion from µM to mg/kg in the P2 ABSSSI study:
Cmax in plasma was 7.67 µM from a single IV dose of 0.6 mg/kg.
Cmax is the maximum concentration in the blood stream.

I want to stress that I'm an investor, not a scientist. I read scientific papers with the aim of understanding how they might affect an investment I have or may make.