It should. Simultaneous quad editing of T-cells using BEAM's base editor (CBE; C-to-T) resulted in no detected aberrant karyotypes compared to Cas9* edited cells with the same four gRNAs producing twenty-two aberrant karyotypes (100 cells evaluated).
Based edited cells (again, BEAM's own data) decreased expression of the four targeted genes (efficacy of 94-98% at each target gene), but had only minimal effect on other genes, while Cas9* induced differential expression of over 1,500 genes, including the p53 pathway.
* Keep in mind that CRSP and others continue to enhance their Cas9 systems through protein engineering, as well as identifying optimal gRNAs (both formats and sequences). So an apples to pears comparison.
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