It's hard to know yet about how serious this is, but the notion of long covid, or the cumulative effect of multiple infections is concerning.
If we are seeing a lag in coverage in vaccines, or fewer people getting boosted, fewer precautions it seems likely that with more infections will come a need for a good antiviral.
Enanta may have a superior antiviral to Paxlovid, and it would appear that the need for one is going to increase. Fauci himself, had a case of what was called "Paxlovid rebound".