Difference in systemic and mucosal immunoglobulin (Ig)A and IgG concentrations and specificities. Correlations of gp41 Env-specific (a) IgG and (b) IgA in genital secretions vs. plasma during acute HIV-1 infection (AHI). Correlations of (c) plasma and (d) mucosal levels of HIV-1 Env-specific IgG vs. IgA during AHI. Specific activity in mucosal samples is calculated as µg of HIV-specific antibody (Ab) per mg total Ab. Concentrations of anti-gp41 Ab calculated per 2F5 monoclonal Ab equivalents and concentrations of anti-gp120 Abs are calculated as the binding units in the linear range multiplied by the dilution factor divided by total Ab concentration.Download Power Point slide (312 KB)