Nowhere in the first article you linked to, do they claim that Appalachia was specifically targeted. Yes, that area was hit hardest, maybe, but that's really a different issue.
The problem with these rich blowhards like Manchin complaining about the costs of proposed government programs is that he, and they, were nowhere to be found during Trump's $1T giveaway tax cut to the most wealthy. Because that benefited the political donors class.
Manchin's new found fiscal responsibility religion is in the service to his masters. Despite the numerous efforts of the current administration and various economists to explain that the programs will not cost most taxpayers anything more.
Even if something like universal pre-school does cost us money - in the short run - there's ample proof that it will save money in the long run:
What shitheels like Manchin insist on ignoring is that wealth inequality is one of the biggest threats to our overall financial stability and democratic norms.