Achilles Therapeutics Plc (ACHL)

[jondoeuk]

No, but the data its trained on is designed to distinguish tumour DNA from non-tumour DNA and clonal from sub-clonal neoantigens*. For any clonal sequences, they create peptides and use them for (patient-derived) DC co-culture, before T-cells (both CD4+ and CD8+) are added, reactivates are identified, and then selective expansion of them.

In 2H there will be additional low-dose mono data, higher-dose (Process 2) mono data, and combo data (plus Opdivo in melanoma, NSCLC is slightly behind).




* https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001906 https://www.nejm.org/doi/full/10.1056/NEJMoa1616288 https://www.nature.com/articles/s41586-019-1032-7 https://www.nature.com/articles/nature22364