PRDS—Ritonavir-related excerpt from S-1 filing (for registration of insider shares): https://www.sec.gov/ix?doc=/Archives/edgar/data/0001822711/000119312522014843/d299901ds1.htm In August 2021, we initiated our first-in-human trial for PBI-0451. This trial is anticipated to enroll up to 180 healthy volunteers. The Phase 1 study is a placebo-controlled, blinded, randomized, dose escalation study of PBI-0451 in healthy volunteers designed to evaluate the safety, tolerability, and pharmacokinetics of PBI-0451 after single and multiple ascending doses. This study will also evaluate the drug-drug interaction potential of PBI-0451, including upon its coadministration with ritonavir. Emphasis added.