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Re: DewDiligence post# 241123

Monday, 01/24/2022 3:20:22 PM

Monday, January 24, 2022 3:20:22 PM

Post# of 249855
PRDS—Ritonavir-related excerpt from S-1 filing (for registration of insider shares):

In August 2021, we initiated our first-in-human trial for PBI-0451. This trial is anticipated to enroll up to 180 healthy volunteers. The Phase 1 study is a placebo-controlled, blinded, randomized, dose escalation study of PBI-0451 in healthy volunteers designed to evaluate the safety, tolerability, and pharmacokinetics of PBI-0451 after single and multiple ascending doses.

This study will also evaluate the drug-drug interaction potential of PBI-0451, including upon its coadministration with ritonavir.

Emphasis added.

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