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Re: dewophile post# 41527

Friday, 02/02/2007 2:43:34 PM

Friday, February 02, 2007 2:43:34 PM

Post# of 257648
We’re in full agreement about the nature of the risk-reward tradeoff. However, I think VRTX will take the position that they’re the leader and hence they will want to be compensated for taking any risk at all in running a combo trial with another antiviral agent.

Assuming for the sake of discussion that the agent to be tested with VX-950 is NM283, I think VRTX will likely insist that:

1. NVS pay all expenses of planning and running the combination study; and

2. NVS pay an up-front fee to VRTX, perhaps in the form of an equity purchase at a premium to the market price.

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