HBV—Perhaps the best one can hope for is to improve upon current SoC.
What kind of improvement short of a functional cure would be worth achieving? In my opinion, there isn’t any such improvement. Nuc monotherapy, given indefinitely, is effective at suppressing HBV DNA to undetectable levels and preventing disease progression.
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”