Curative Biotechnology Inc (CUBTD)

[oxnous]

Look at this from that Linked IN link.

Kapil Bharti

2nd degree connection 2nd

Senior Investigator at The National Institutes of Health
1w

Excited to work with Curative Biotech on evaluating metformin eye drops as a potential treatment for retinal degenerative diseases. This technology showed promising results in preclinical studies performed using patient stem cell derived eye cells. Two publications on the way.

3 Replies on Kapil Bharti’s comment

See profile for Rajarshi Pal, Ph.D.

Chief Scientist, Eyestem Research, Centre for Cellular and Molecular Platforms (C-CAMP), NCBS-TIFR Campus, Bangalore

1w
That’s amazing news! Metformin is a pleiotropic molecule and unsurprisingly there is evidence of its therapeutic potential in AMD patients, through retrospective trials. However knowing the mechanism would be exciting- perhaps through its role as a TGF-beta inhibitor!??

See profile for Kapil Bharti
Kapil Bharti

Senior Investigator at The National Institutes of Health
1w

Rajarshi Pal, Ph.D. Thanks Raj! As your said, it’s a pleiotropic molecule. We see effects on lipid metabolism, mitochondrial function, cell polarity, and EMT.


Rajarshi Pal, Ph.D.

Chief Scientist, Eyestem Research, Centre for Cellular and Molecular Platforms (C-CAMP), NCBS-TIFR Campus, Bangalore

6d
Kapil Bharti Wow, sounds very interesting! Earlier, we too had identified the role of metformin in type 1 and type 3 EMT using stem cell lines and validated the mechanisms in an animal model and patients respectively.

https://stemcellsjournals.onlinelibrary.wiley.com/doi/10.1002/stem.2245

https://link.springer.com/article/10.1007%2Fs00109-016-1455-7