Gene therapies involve making deliberate changes to a patient’s DNA in order to cure or alleviate a genetic condition. This can be by adding a functional copy of a gene, disabling a gene that makes a faulty product or changing gene activation.
The mRNA from the vaccines does not enter the cell nucleus or interact with the DNA at all, so it does not constitute gene therapy.
Gene therapies simply are defined as:
Gene therapy represents the introduction of genetic material into an individual’s cells and biological tissues.
mRNA is a genetic material introduced into an individual's cells, so mRNA vaccines are gene therapies.
Gene therapies typically do not modify or alter DNA, and the mRNA vaccines don't do that.
The alteration of genetic material is called gene editing.
Unless somehow people are saying mRNA is not genetic material.
The American Society of Gene and Cell Therapy certainly classifies mRNA vaccines as gene therapy:
Today’s FDA approval of the COVID-19 vaccine BNT162b2 from Pfizer and BioNTech marks a great day for the USA and a significant milestone for the field of gene and cell therapy.
Because the vaccine introduces new genetic material into cells for a short period of time to induce antibodies, it is a gene therapy as defined by ASGCT. The mRNA in Comirnaty does not alter the recipient’s genetic material and is only present in the body transiently.
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