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Re: cowtown jay post# 33693

Wednesday, 09/29/2021 12:38:42 PM

Wednesday, September 29, 2021 12:38:42 PM

Post# of 43396
It's interesting to note that Dale's partner in all four of the publications I linked, Nicholas P Restifo, is in the same area as Humanigen, and has also kept his career focused on the, "Successful treatment of patients with cancer is the goal of his laboratory, and his therapeutic approaches employ adoptive T cell transfer, gene modification and cellular reprogramming.[6] Basic aspects of tumor and T cell immunology inform novel therapeutic interventions in the clinic.

Restifo and his research team have made contributions to the fields of adoptive cell transfer[7] tumor immune-escape,[8][9] virally encoded cancer vaccines,[10] adoptive cell transfer for the treatment of cancer, and the biology of self/tumor-reactive T cells, with an emphasis on memory CD8+ T cells."

https://en.wikipedia.org/wiki/Nicholas_P._Restifo

Humanigen has an, "...exclusive worldwide license with the Mayo Clinic to certain technologies used to create CAR-T cells lacking GM-CSF expression through various gene-editing tools including CRISPR-Cas9 (GM-CSF knock-out). The license covers various patent applications and know-how developed by Mayo in collaboration with Humanigen. These licensed technologies complement and broaden Humanigen’s leadership position in the GM-CSF neutralization space and expand Humanigen’s discovery platform aimed at improving CAR-T to include gene-edited CAR-T cells."

https://ir.humanigen.com/English/news/news-details/2019/Humanigen-Secures-Exclusive-Worldwide-License-to-Gene-Editing-Technology-from-Mayo-Clinic-to-Improve-CAR-T/default.aspx
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