12-week response rate was not a standard endpoint used in oncology - therefore how predictive it will be of PFS and OS will be unknown.
Having said that, the added toxicity of triple may have shortened the treatment duration - and thus lower the chance for success in the future.
This is a medical affairs trial - so may not be respresentative of those in clinical development - which has trial program that essentially mimic the EPIC, the Crystal etc. Third-line rr seem to be rather comparable between the two drugs.