you are not alone in seeking this info... it has not been provided (that is recent data post April 06)
If IDIX and NVS can mitigate the GI effects of higher doses of NM283 w/ something "creative"... the word "creative" used in past CC... the treatment refractory area may be a more fertile area for NM283 than treatment naive.
progress to date on the refractory side is a (?) @ present.
The creation of a thousand forests is in one acorn.