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Thursday, May 20, 2021 11:33:54 AM
CpG 1018 is a recently developed adjuvant used in Heplisav-B vaccine. It is made up of cytosine phosphoguanine (CpG) motifs, which is a synthetic form of DNA that mimics bacterial and viral genetic material. When CpG 1018is included in a vaccine, it increases the body’s immune response.
In pre-licensure clinical trials, adverse events after Heplisav-B were comparable to those observed after another U.S.-licensed, non-adjuvanted hepatitis B vaccine.
https://www.cdc.gov/vaccinesafety/concerns/adjuvants.html
https://pubmed.ncbi.nlm.nih.gov/25344321/
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