Right after Pfizer abandoned Torcetrapib, Genentech rushed into a partnership with Bioinvent on a drug for cardiovascular conditions still in preclinical. Liponex should report results of a phase 2 in few months but had to cut the highest dose due to patients suffering from diarrhea...the company assured shareholders that a much smaller dose would be as effective and that the 5mg now off limit was impractical in any case.
Maybe liponex using 2mg would end up with a drug that regulates cholesterol levels and provides regularity to seniors? lol.
Liponex suspends high-dose clinical on diarrheal effect Thursday, January 4, 2007
Drug developer Liponex Inc. has suspended treating patients at the highest dose level of its good cholesterol-raising CRD5 drug in a mid-stage clinical. The Ottawa-based company said it encountered an "unacceptable high level" of patients dropping out of the trial because of diarrhea when taking five grams of the drug a day. There have been no serious adverse events reported. Patients now receiving one gram and three grams of daily dosing will continue to be treated under the existing trial protocol. The company has previously indicated that it didn't believe a five-gram pill represented a commercial option because it required too many pills to be taken daily. http://www.workopolis.com/servlet/Content/fasttrack/20070104/RTICKER04-3?section=Biotech
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