- The company Vaxart (NASDAQ: VXRT) from San Francisco has been developing oral vaccinations against the diarrhea-causing norovirus and against the uterine cancer-causing papillomavirus for a long time.
Together with Janssen (subsidiary of Johnson & Johnson) she is developing an oral flu vaccination, which in a phase II study gave better results than an established injection vaccination - if confirmed by a phase III study, that would be an absolute sensation.
Vaxart's Covid vaccine gave good protection in animal studies, and a Phase I human trial produced cellular immunity and local Ig-A antibodies, but no IgG antibodies in serum, causing the share price to fall.
This seems unjustified because one in sixteen Covid healed people also has no serum antibodies , and because animal experiments have shown that cellular immunity protects against low levels of antibodies .
And if that vaccination prevented the virus from reaching the bloodstream, the lack of serum antibodies wouldn't be a disadvantage. Only clinical trials can clarify this.