"is it likely that NM283 is being considered primarily for use in combination with protese inhibitors or albuferon, thus the change in the anticipated filing dates?"
do not agree w/ this logic...
I believe the reason for the change in date is a progression towards the current reality; that is, P3 on NM283 most likely will run from 2008 - 2009+
Dr. Brown resigned as CMO and will remain as a Senior Advisor.
I do not have a "read" on the reason for the resignation nor was one offered by Idenix PR release.
It does appear the new CMO, Dr Mayers, is well qualified and should be a good fit given bigger push into HIV drugs.
The creation of a thousand forests is in one acorn.
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