Relief Therapeutics Holding AG (RLFTF)

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MORE ON A TREASURE TROVE OF SCIENCE

The deadliest disease in the world is coronary artery disease (CAD). Also called ischemic heart disease, CAD occurs when the blood vessels that supply blood to the heart become narrowed. Untreated CAD can lead to chest pain, heart failure, and arrhythmias.

https://www.healthline.com/health/top-10-deadliest-diseases

In research animals and in humans, VIP, administered into the coronary artery or intravenously, increases the epicardial coronary artery cross-sectional area, decreases coronary vascular resistance, and significantly increases coronary artery blood flow. High frequency parasympathetic (vagal) nerve stimulation also releases endogenous VIP in the coronary vessels and heart and significantly increases coronary artery blood flow. In addition, the release of VIP in the heart is increased during coronary artery occlusion and during reperfusion where VIP may promote local blood flow and may have a free-radical scavenging effect. VIP also has a primary positive inotropic effect on cardiac muscle that is enhanced by its ability to facilitate ventricular-vascular coupling by reducing mean arterial pressure by 10-15%. In concentrations of 10(-8)-10(-5) mol, VIP augments developed isometric force and increases atrial and ventricular contractility. The presence of VIP-immunoreactive nerve fibers in and around the sinus and the atrioventricular nodes of mammals strongly suggests that this peptide can affect the heart rate. In this regard, endogenously released or exogenous VIP can significantly increase the heart rate and has a more potent effect on heart rate than does norepinephrine. The presence and significant cardiovascular effects of VIP in the heart suggests that this peptide is important in the regulation of coronary blood flow, cardiac contraction, and heart rate. Current investigations are defining the physiological role of VIP in the regulation of cardiovascular function.

https://pubmed.ncbi.nlm.nih.gov/11121793/

Cardiovascular Drugs Market to reach USD 63.96 Billion by 2026; Growing Need for Advanced and Effective Drugs to Propel Growth, says Fortune Business Insights

https://www.globenewswire.com/news-release/2019/11/26/1952618/0/en/Cardiovascular-Drugs-Market-to-reach-USD-63-96-Billion-by-2026-Growing-Need-for-Advanced-and-Effective-Drugs-to-Propel-Growth-says-Fortune-Business-Insights.html