Algernon Health Inc (AGNPF)

[Money $hot]

You know it's hell when I come through...

It's A Hard Knock Life for Us


cen.acs.org/pharmaceuticals/drug-discovery/Is-drug-repurposing-worth-the-effort/99/i3

To date, all cases of successful drug repurposing for any disease have come from either the observations of astute clinicians or a deep understanding of drugs’ mechanisms of action, says Aled Edwards, founder and CEO of the Structural Genomics Consortium, a nonprofit that supports drug discovery efforts. Edwards says no large-scale laboratory screening effort has found an old drug that has been approved for a new indication. And he argues that the odds of finding a successful COVID-19 drug from such efforts is essentially nil.

“It’s not impossible, so it’s not a dumb idea to check just in case,” Edwards says. “But don’t bet your government’s COVID strategy on it.”

Derek Lowe, a pharmaceutical chemist who writes the popular In the Pipeline blog, agrees. “I think you have to try it because your barrier to entry is low, and if you do find something, you can go directly into patients. There’s nothing else that has that short a turnaround,” he says. “At the same time, that’s balanced out by the odds being really, really low that anything is going to actually work.”

Carter at ISAR says no one expects repurposing screens to identify more than a few useful drugs for any particular indication. Even so, she says, “repurposed efforts always need to be deployed when you have the emergence of a new disease, because if there is something that’s readily addressable to the population, you absolutely want to identify it rapidly and take it forward.”

In another's words...

Let's stick up the world and split it 50/50, uh-huh
Let's take the dough and stay real jiggy, uh-huh
And sip the Cris' and get pissy-pissy
Flow infinitely like the memory of my n*gga Biggie, baby!

M$

Postscript

go.drugbank.com/drugs/DB08954

Outro