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Re: DewDiligence post# 236803

Thursday, 01/21/2021 10:34:25 AM

Thursday, January 21, 2021 10:34:25 AM

Post# of 257443
RE: ENTA HBV RNA de-stabilizer (EDP-721).

My point was to compare multi-pronged attacks in HCV to HBV. I'm not sure if it's fair to compare ribavirin to a destabilizer, but it seemed somewhat analogous.

The ENTA de-stabilizer EDP-721 looks much better than ribavirin as second component of attack.
Their mouse model shows a 3 log drop at day 14 with EDP-721.
ENTA's antiviral EDP-514 achieved a 4 log drop.
It remains to be seen what will happen in phase 1.

Am I understanding that there will be a presumed required 3rd component; a NUC?

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