Mymetics Corp (MYMX)

[Work Harder]

Harnessing Cellular Immunity for Vaccination
against Respiratory Viruses

Chart pg 5

then

For example, one study found
that inclusion of the TLR4 ligand monophosphoryl lipid A (MPLA) in reconstituted RSV membranes
(virosomes) potentiated vaccine-induced immunity and skewed the immune responses toward a
Th1 phenotype, without priming for ERD [88] as with alum adjuvanted RSV vaccines, suggesting
a safer more effective vaccination strategy. Incorporation of Pam3CSK4, a TLR2 agonist, increased
the capacity of virosomes to activate APCs in vitro and boosted serum IgG antibody responses and
mucosal antibody responses after immunization and protected mice against infection with RSV, without
priming for enhanced disease [89]. Studies have also shown that TLR9 activation can protect against
vaccine-enhanced disease [90]. Vaccine formulations with the inclusion of TLR7/8 agonists, such as
imiquimod, have historically been difficult to deliver due to their small molecular size; however,
recently, the incorporation of these molecules into new delivery systems, such as nanoparticles,
has garnered some success [91]. Together, these studies support the idea that proper TLR-activating
adjuvants and APC targeting may significantly change the landscape for respiratory viral vaccination
towards safer and more efficacious options.

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&ved=2ahUKEwjhm8HS4KjuAhUKHc0KHTvoDdQQFjAEegQIBRAC&url=https%3A%2F%2Fwww.mdpi.com%2F2076-393X%2F8%2F4%2F783%2Fpdf&usg=AOvVaw3QzH4Fe5YH6kInJv3RvPnA

88. Kamphuis, T.; Shafique, M.; Meijerhof, T.; Stegmann, T.; Wilschut, J.; de Haan, A. Efficacy and safety of an
intranasal virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A in mice
and cotton rats. Vaccine 2013, 31, 2169–2176. [CrossRef]

https://adisinsight.springer.com/trials/700297229

Not that it's related but it is in the google resluts as below

Influenza virus vaccine intranasal - Mymetics, Phase I, Mymetics Corporation ... J. Lewis Research, Inc. - Jordan River Family Medicine, South Jordan, Utah, USA.

https://clinicaltrials.gov/ct2/show/NCT03572062