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Re: Work Harder post# 22121

Friday, 12/25/2020 8:59:18 PM

Friday, December 25, 2020 8:59:18 PM

Post# of 27661
virosomes we used do not contain phosphatidylserine, so the interaction of 24 KIM-1 with this phospholipid cannot explain the KIM-1 mediated facilitation of uptake

. Our
3 finding that TW-37 blocked entry of the SARS-CoV-2 virosomes suggests prevention of viral internalization
4 as an approach to anti-SARS-CoV-2 viral treatment. This would be reminiscent of the use of Enfuvirtide,
5 Maraviroc and Ibalizumab for HIV where administration of agents that will bind to the virus in the circulation
6 will compete for tissue binding (Henrich and Kuritzkes, 2013).
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