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Virucidal Activity of World Health Organization-Recommended Formulations Against Enveloped Viruses, Including Zika, Ebola, and Emerging Coronaviruses.
Siddharta A1, Pfaender S2, Vielle NJ2, Dijkman R2, Friesland M1, Becker B3, Yang J4, Engelmann M1, Todt D1, Windisch MP4, Brill FH3, Steinmann J5, Steinmann J3, Becker S6, Alves MP2, Pietschmann T1, Eickmann M6, Thiel V2, Steinmann E1
Author information
Affiliations
6 authors
1. Institute of Experimental Virology, Twincore, Centre for Experimental and Clinical Infection Research, Hannover, Germany.
5 authors
2. Federal Department of Home Affairs, Institute of Virology and Immunology, Bern and Mittelhäusern, Switzerland.
3 authors
3. Dr Brill + Partner GmbH Institute for Hygiene and Microbiology, Bremen, Germany.
2 authors
4. Applied Molecular Virology, Institut Pasteur Korea, Seongnam, Gyeonggi-do, South Korea.
1 author
5. Institute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Duisburg, Germany.
2 authors
6. Institute for Virology, Philipps University of Marburg, Germany.
ORCIDs linked to this article
Pfaender S,0000-0002-3957-5448, Institute of Virology and Immunology IVI
Dijkman R,0000-0003-0320-2743, Institute of Virology and Immunology
Todt D,0000-0002-3564-1014, Ruhr-Universität Bochum
Pietschmann T,0000-0001-6789-4422, TWINCORE Zentrum für Experimentelle und Klinische Infektionsforschung GmbH
Thiel V,0000-0002-5783-0887, University of Bern
The Journal of Infectious Diseases, 28 Feb 2017, 215(6):902-906
DOI: 10.1093/infdis/jix046 PMID: 28453839 PMCID: PMC5407053


Abstract
The World Health Organization (WHO) published 2 alcohol-based formulations to be used in healthcare settings and for outbreak-associated infections, but inactivation efficacies of these products have not been determined against (re-)emerging viruses. In this study, we evaluated the virucidal activity of these WHO products in a comparative analysis. Zika virus (ZIKV), Ebola virus (EBOV), severe acute respiratory syndrome coronavirus (SARS-CoV), and Middle East respiratory syndrome coronavirus (MERS-CoV) as (re-)emerging viral pathogens and other enveloped viruses could be efficiently inactivated by both WHO formulations, implicating their use in healthcare systems and viral outbreak situations.

https://europepmc.org/article/MED/28453839