Humanigen Inc (fka HGENQ)

[misiu143]

Tscott4- why you saying Leronlimab will not work ...

We know already that it is working ..

M/M study showed Clinically Significant primary endpoint , less objective symptoms ..
And Statistically Significant secondary more objective symptoms NEWS2..

One mistake in this study imo was that they took any patients , if they will concentrate only on patients over 65 and at risk , results should be even more dramatic ..

And they had 65 patients in EIND ..
Those were the most critical not responding to any other treatment ,
yes , few died , but many came off ventilator or ECMO..

Lenzilumab working by affecting GM-CSF
But according to Dr Patterson only 20-30% of patients with covid have elevated GM-CSF.

And in the long haulers GM-CSF is low , but every patient with mild or severe problem has high Rantes

And with Lenzilumab primary endpoint was changed already from mortality to much less important , length of hospitalization ..
And after 50% interim , more patients was added , this mean to me that even this endpoint was difficult to meet ..

No , I personally am not worry about results of Leronlimab S/C study , all indications that Leronlimab will pass , having very difficult mortality as a primary endpoint ..

GLTU

All imo