LMAO Alum!!! Virosome work 100 times better!!!! :)
This what am talking about!! :) The STING-TBK1-IRF3 axis has also been involved in the adjuvant activity of c-di-GMP. Cyclic-di-GMP is a bacterial signaling molecule with strong immunostimulatory activity, which is currently being investigated as a mucosal adjuvant [3, 4].
4. Pedersen GK. et al., 2011. Evaluation of the sublingual route for administration of influenza H5N1 virosomes in combination with the bacterial second messenger c-di-GMP. PLoS One. 6(11):e26973.
3. Chen W. et al., 2010. The potential of 3',5'-cyclic diguanylic acid (c-di-GMP) as an effective vaccine adjuvant. Vaccine. 28(18):3080-5 (review).