GTC Biotherapeutics (fka GTCB)

[gym gravity]

factor vii publication:


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&l...

1: Anaesthesia. 2007 Jan;62(1):43-52. Links
Cost effectiveness of recombinant activated factor VII for the control of bleeding in patients with severe blunt trauma injuries in the United Kingdom.

* Morris S,
* Ridley S,
* Munro V,
* Christensen MC;
* the NovoSeven Trauma Study Group.

Reader, Health Economics Research Group, Brunel University, Uxbridge, Middlesex UB8 3PH, UK.

Summary The aim of this study was to assess the lifetime cost effectiveness of recombinant activated factor VII vs placebo as adjunctive therapy for control of bleeding in patients with severe blunt trauma in the UK. We developed a cost-effectiveness model based on patient level data from a 30-day international, randomised, placebo-controlled Phase II trial. The data were supplemented with secondary data from UK sources to estimate lifetime costs and benefits. The model produced a baseline estimate of the incremental cost per life year gained with recombinant activated factor VII relative to placebo of pound12 613. The incremental cost per quality adjusted life year gained was pound18 825. These estimates are sensitive to the choice of discount rate and health state utility values used. Preliminary results suggest that relative to placebo, recombinant activated factor VII may be a cost-effective therapy to the UK National Health Service.