Friday, October 23, 2020 10:58:36 AM
@nelskof
The PhaseBio VIP Derivative is made so it's half life is increased. the theory being increase half life and Increase bioavailability of the hormone to fight covid.
The likely issue with PhaseBio's drug is the delivery being subcutaneous (Subq) In patients infected with Covid and suffering from O2 deprivation they don't want walk or move. SUBQ relies on the lymphatic system for delivery, This system is not under pressure like the arterial blood portion of the the peripheral circulatory system.
Without the patient wanting to move about....the lymphatic fluid doesn't move... without movement of lymphatic fluid, no delivery of VIP...no delivery of VIP but no side effects either... One is a plus and good to know the other is good to know as well.. You have to deliver VIP directly to the lungs as in IV....Dr. Javitt even said he wouldn't use Inhalers on Severe/critical because the chace was you needed a more direct delivery that being the arterial system of the Blood stream
The PhaseBio VIP Derivative is made so it's half life is increased. the theory being increase half life and Increase bioavailability of the hormone to fight covid.
The likely issue with PhaseBio's drug is the delivery being subcutaneous (Subq) In patients infected with Covid and suffering from O2 deprivation they don't want walk or move. SUBQ relies on the lymphatic system for delivery, This system is not under pressure like the arterial blood portion of the the peripheral circulatory system.
Without the patient wanting to move about....the lymphatic fluid doesn't move... without movement of lymphatic fluid, no delivery of VIP...no delivery of VIP but no side effects either... One is a plus and good to know the other is good to know as well.. You have to deliver VIP directly to the lungs as in IV....Dr. Javitt even said he wouldn't use Inhalers on Severe/critical because the chace was you needed a more direct delivery that being the arterial system of the Blood stream
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