Mymetics Corp (MYMX)

[Work Harder]

A Novel LNP-based Chlamydia subunit vaccine formulation that induces Th1 responses without upregulating IL-17 provides equivalent protection in mice as formulations that induced IL-17 and Th1 cytokines

Merck & Co Inc

Both vaccine formulations generated robust immunological responses and both vaccine formulations were protective by reducing bacterial shedding after challenge.

This data indicates equal protection can be achieved without the induction of Th17 responses.

https://www.researchsquare.com/article/rs-7390/v1

The potential role of Th17 immune responses in coronavirus immunopathology and vaccine-induced immune enhancement

Peter J. Hotez*

Maria Elena Bottazz

Biology of Inflammation Center, Department of Medicine and Pathology & Immunology, The Michael E. DeBakey Center for Translational Research in Inflammatory Diseases, Baylor College of Medicine, Houston, TX, USA

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162764/

Such findings help explain the link between viral-vectored coronavirus vaccines and immune enhancement and its reduction through alum adjuvant