Mymetics Corp (MYMX)

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The SARS-CoV-2 Vaccine Pipeline: an Overview | Request PDF
www.researchgate.net/publication/339657965_The...
Maria Elena Bottazzi. 42.72; ... Spike protein has 2 functional domains S1 domain in charge of receptor binding and S2 domain in charge for membrane fusion [22]. ... expressing SARS-CoV-2 proteins ...
https://www.researchgate.net/publication/339657965_The_SARS-CoV-2_Vaccine_Pipeline_an_Overview


Inhibition of Influenza-induced Membrane Fusion
Upon addition of virus to liposomes at pH 5.1, 37°C, there was an increase in fluorescence caused by membrane fusion (Stegmann et al., 1986)
https://www.jbc.org/content/270/49/29279.full

Fusion is triggered by low pH, which induces conformational changes in the protein, leading to insertion of a hydrophobic 'fusion peptide' into the viral Author: Toon Stegmann
Publish Year: 2000 brane and the target membrane for fusion.

https://pubmed.ncbi.nlm.nih.gov/11208147/

Toon Stegmann, Shlomo Nir, and Jan Wilschut. Membrane fusion activity of influenza virus. Effects of gangliosides and negatively charged phospholipids in target liposomes.
https://pubs.acs.org/doi/10.1021/bi00365a014

Intermediates in influenza induced membrane fusion
Toon Stegmann. 33.44; Mymetics SA; Judith White. 44.2; ... (HA, the viral fusion protein) and in the contact site between virus and target membrane. To render individual steps amenable to study ...

https://www.researchgate.net/publication/20889678_Intermediates_in_influenza_induced_membrane_fusion