Mymetics Corp (MYMX)

[bow-tie]

Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA

Mammalian immune responses are initiated by “danger” signals––immutable molecular structures known as PAMPs. When detected by fixed, germline encoded receptors, pathogen-associated molecular pattern (PAMPs) subsequently inform the polarization of downstream adaptive responses depending upon identity and localization of the PAMP. Here, we report the existence of a completely novel “PAMP” that is not a molecular structure but an antigenic pattern. This pattern––the incidence of peptide epitopes with stretches of 100% sequence identity bound to both dendritic cell (DC) major histocompatibility (MHC) class I and MHC class II––strongly induces TH1 immune polarization and activation of the cellular immune response. Inherent in the existence of this PAMP is the concomitant existence of a molecular sensor complex with the ability to scan and compare amino acid sequence identities of bound class I and II peptides. We provide substantial evidence implicating the multienzyme aminoacyl-tRNA synthetase (mARS) complex and its AIMp1 structural component as the key constituents of this complex. The results demonstrate a wholly novel mechanism by which T-helper (TH) polarization is governed and provide critical information for the design of vaccination strategies intended to provoke cell-mediated immunity.
https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fj.201903002R

Immunogenicity and Protective Capacity of a ... - MyMetics
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Molecular Patterns (PAMPs) from bacteria and viruses and sub-sequently signal through adaptor molecules such as MyD88 and TRIFtoinducetheproductionofinflammatorycytokinesandtype-I interferons [19]. Activation of TLR4, for example, leads to production of high amounts of IL12 and IFNc resulting in a Th1-skewed immune response [20].

University of Groningen Toward a virosomal respiratory ...
www.rug.nl/research/portal/files/67431355/...
Molecular Patterns (PAMPs) from bacteria and viruses and subsequently signal through ... RSV strain A2 (ATCC VR1540) was kindly donated by Mymetics BV (Leiden, The ...