GTC Biotherapeutics (fka GTCB)

[DewDiligence]

Re: Lipoxen and clotting-factor stability

>Do these guys understand how the coagulation cascade works?? The system is based on critical concentrations of factors allowing the sequence to proceed. Factor instability is critical to decrease the chance of unwanted thrombosis.<

The active forms of the clotting factors—the factors with an “a” suffix such as FVIIa—need to be unstable for the cascade to work. However, the inactive clotting factors—the ones without an “a” suffix—are present in circulating plasma at all times, which is what allows the cascade to begin anywhere in the body whenever there’s an injury.

For hemophiliacs who need regular augmentation of an inactive clotting factor (FVIII for hemophilia A and FIV for hemophilia B), a longer product half-life to allow less frequent injections would be desirable—provided of course that there were no safety issues. Regards, Dew