The OWC multiple myeloma study was done by three repetitive tests on the effect of cannabis extract with various combination ratios of THC/CBD and pure THC and CBD (50% concentration). The results present more than 60% malignant cell death. More results of pure THC and CBD are under further analysis.
Multiple myeloma cells were cultured for 48 hours with CBD and THC (all cannabis extracts) as compare to their combinations - CBD: THC 1:1; CBD: THC 5:1 and CBD: THC 1:5. Combination Index (CI) value <1, =1, >1 indicates synergism, additive effect, and antagonism, respectively. Each treatment was performed in triplicate in four independent experiments and presented as mean. The treatment of CBD in combination with THC had synergistic effect, being their cytotoxic effect is higher with each of the three combinations tested.
CBD and THC decreased survival of multiple myeloma cells in a concentration-dependent manner.
Multiple myeloma, a cancer of plasma cells in the bone marrow, accounts for 10% of all hematologic malignancies. It is the second most common hematologic cancer and represents 1% of all cancer diagnoses and 2% of all cancer deaths.
The basic science phase of the study has begun several weeks ago, at the Sheba Academic Medical Center (affiliated with Tel-Aviv University). Dr. Merav Leiba, Head of Sheba's Multiple Myeloma Service and Multiple Myeloma Research Lab is leading the study. The company conducts the study in accordance with Sheba's Internal Review Board (IRB) approval.
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