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jondoeuk

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jondoeuk

Re: DewDiligence post# 228381

Saturday, 01/25/2020 5:27:55 PM

Saturday, January 25, 2020 5:27:55 PM

Post# of 252301
In this preclinical paper NUC therapy, (DNA) vaccination and an anti-PD-L1 (not indefinitely) led to viral clearance in a subset [1]. Also, clinical data on PD-1 receptor occupancy (and more) after a single infusion of Opdivo was provided in this [2]. So I think anti-PD(L)-1 inhibitors could play a role in a potentially 'curative' regimen, but the real question is how many agents will be needed.

1 https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1003856
2 https://www.journal-of-hepatology.eu/article/S0168-8278(19)30400-3/fulltext
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