Avid Bioservices Inc (CDMO)

[biopharm]

John Springs Stafford did not come into the picture to break up the IP ...allowing it to be shifted to Oncologie Inc with ex Eli Lilly groupies led by CEO Laura Benjamin ...for no reason at all.

Some could say he did so ....so the new CDMO Avid Bioservices can fast track to stardom (without the drag of R&D etc on IP assets) but the BOD at Avid, for a company that IS CASH FLOW POSITIVE have been nothing short of scared it seems...and the analysts? Hell, the analysts seem to have no clue what it means to initiate or to trigger all protein pathway events. Maybe they can call Stryker and see why they picked up "Mobius Imaging" that at the cellular level...it is astronomical as to what one sees AFTER PS Targeting

Looks like those EXOSOMES have flipped PS and yes, worth Billions if one has the patents on Targeting flipped PS


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Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA

Asako Shimoda,
Koji Ueda,
Shin Nishiumi,
Naoko Murata-Kamiya,
Sada-atsu Mukai,
Shin-ichi Sawada,
Takeshi Azuma,
Masanori Hatakeyama &
Kazunari Akiyoshi

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Introduction
Helicobacter pylori is a gram-negative bacterium that colonises the human stomach. Nearly half of the world population has been estimated to be carriers of H. pylori and infection with H. pylori is associated with the pathogenesis of gastric disorders, such as atrophic gastritis, peptic ulcers and gastric cancer1,2,3. Among reported H. pylori virulence factors, much attention has been focused on CagA, a protein encoded by cytotoxin associated gene A (cagA), because of its strong association with severe gastric lesions, particularly gastric cancer4,5. CagA is a bacterial effector protein that is injected into gastric epithelial cells via the type IV secretion system (T4SS). Inside host epithelial cells, CagA undergoes....

( *** Hold on a minute, it just said "inside host epithelial cells..." but HOW ?? ....let me repost some highlights from the most up to date research that has been known for quite some time by some, and will be in the hands of new IIS now *** )
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https://www.nature.com/articles/srep18346

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To further facilitate the delivery of CagA, H. pylori induces the membrane phospholipid phosphatidylserine (PS) found in the inner membrane leaflet of epithelial cells to be exposed on the outer membrane.63

CagA interacts with the exposed PS to initiate its secretion into the host epithelial cell.
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CagA, which is also exposed on the bacterial surface via type IV secretion, interacts with the membrane-externalized PS. The CagA-PS interaction triggers the entry of CagA into host epithelial cells, which also requires energy-dependent host cell processes distinct from known endocytic pathways.

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