![](http://investorshub.advfn.com/images/default_ih_profile2_4848.jpg?cb=0)
Friday, December 06, 2019 10:15:39 AM
Some could say he did so ....so the new CDMO Avid Bioservices can fast track to stardom (without the drag of R&D etc on IP assets) but the BOD at Avid, for a company that IS CASH FLOW POSITIVE have been nothing short of scared it seems...and the analysts? Hell, the analysts seem to have no clue what it means to initiate or to trigger all protein pathway events. Maybe they can call Stryker and see why they picked up "Mobius Imaging" that at the cellular level...it is astronomical as to what one sees AFTER PS Targeting
Looks like those EXOSOMES have flipped PS and yes, worth Billions if one has the patents on Targeting flipped PS
_________
Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA
Asako Shimoda,
Koji Ueda,
Shin Nishiumi,
Naoko Murata-Kamiya,
Sada-atsu Mukai,
Shin-ichi Sawada,
Takeshi Azuma,
Masanori Hatakeyama &
Kazunari Akiyoshi
.....
....
Introduction
Helicobacter pylori is a gram-negative bacterium that colonises the human stomach. Nearly half of the world population has been estimated to be carriers of H. pylori and infection with H. pylori is associated with the pathogenesis of gastric disorders, such as atrophic gastritis, peptic ulcers and gastric cancer1,2,3. Among reported H. pylori virulence factors, much attention has been focused on CagA, a protein encoded by cytotoxin associated gene A (cagA), because of its strong association with severe gastric lesions, particularly gastric cancer4,5. CagA is a bacterial effector protein that is injected into gastric epithelial cells via the type IV secretion system (T4SS). Inside host epithelial cells, CagA undergoes....
( *** Hold on a minute, it just said "inside host epithelial cells..." but HOW ?? ....let me repost some highlights from the most up to date research that has been known for quite some time by some, and will be in the hands of new IIS now *** )
.....
....
https://www.nature.com/articles/srep18346
_______
...
...
To further facilitate the delivery of CagA, H. pylori induces the membrane phospholipid phosphatidylserine (PS) found in the inner membrane leaflet of epithelial cells to be exposed on the outer membrane.63
CagA interacts with the exposed PS to initiate its secretion into the host epithelial cell.
...
...
___
...
...
CagA, which is also exposed on the bacterial surface via type IV secretion, interacts with the membrane-externalized PS. The CagA-PS interaction triggers the entry of CagA into host epithelial cells, which also requires energy-dependent host cell processes distinct from known endocytic pathways.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=152639424
Recent CDMO News
- Avid Bioservices Reports Financial Results for Fourth Quarter and Fiscal Year Ended April 30, 2024 • GlobeNewswire Inc. • 07/02/2024 08:05:04 PM
- Avid Bioservices to Report Financial Results for Quarter and Fiscal Year Ended April 30, 2024, After Market Close on July 2, 2024 • GlobeNewswire Inc. • 07/01/2024 11:00:21 AM
- Avid Bioservices Earns Committed Badge from EcoVadis for Sustainability Performance • GlobeNewswire Inc. • 05/23/2024 12:05:46 PM
- Avid Bioservices to Participate at Upcoming Investor Conferences • GlobeNewswire Inc. • 05/07/2024 08:05:11 PM
- Avid Bioservices Reports Financial Results for Third Quarter Ended January 31, 2024 • GlobeNewswire Inc. • 04/24/2024 09:25:33 PM
- Avid Bioservices Announces Receipt of Deficiency Notice from Nasdaq Regarding Late Form 10-Q • GlobeNewswire Inc. • 03/20/2024 11:00:10 AM
- Form 8-K - Current report • Edgar (US Regulatory) • 03/07/2024 11:30:11 AM
- Avid Bioservices Announces Pricing of Private Placement of Convertible Notes • GlobeNewswire Inc. • 03/07/2024 04:58:48 AM
- Avid Bioservices Announces Proposed Private Placement of Convertible Notes • GlobeNewswire Inc. • 03/06/2024 09:32:07 PM
- Avid Bioservices Announces Certain Preliminary Financial Results for Third Quarter Ended January 31, 2024 • GlobeNewswire Inc. • 03/06/2024 09:31:28 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 03/06/2024 09:30:18 PM
- Form SC 13G/A - Statement of acquisition of beneficial ownership by individuals: [Amend] • Edgar (US Regulatory) • 01/26/2024 09:57:52 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/13/2024 12:34:35 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/12/2024 12:39:18 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/12/2024 12:38:30 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/12/2024 12:37:38 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/12/2024 12:36:27 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/12/2024 12:35:47 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/11/2024 12:56:02 AM
- Form SC 13G/A - Statement of acquisition of beneficial ownership by individuals: [Amend] • Edgar (US Regulatory) • 01/08/2024 09:32:36 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/04/2024 12:56:18 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/04/2024 12:55:07 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/04/2024 12:53:58 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/04/2024 12:51:57 AM
FEATURED BNCM and DELEX Healthcare Group Announce Strategic Merger to Drive Expansion and Growth • Jul 2, 2024 7:19 AM
EWRC's 21 Moves Gaming Studios Moves to SONY Pictures Studios and Green Lights Development of a Third Upcoming Game • EWRC • Jul 2, 2024 8:00 AM
NUBURU Announces Upcoming TV Interview Featuring CEO Brian Knaley on Fox Business, Bloomberg TV, and Newsmax TV as Sponsored Programming • BURU • Jul 1, 2024 1:57 PM
Mass Megawatts Announces $220,500 Debt Cancellation Agreement to Improve Financing and Sales of a New Product to be Announced on July 11 • MMMW • Jun 28, 2024 7:30 AM
VAYK Exited Caribbean Investments for $320,000 Profit • VAYK • Jun 27, 2024 9:00 AM
North Bay Resources Announces Successful Flotation Cell Test at Bishop Gold Mill, Inyo County, California • NBRI • Jun 27, 2024 9:00 AM