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Thursday, November 07, 2019 2:50:08 PM
Cannabis sativa exists in different chemical variants, showing chemical but sometimes also morphological differences, known as chemotypes (Small and Beckstead 1973). Three different principal chemotypes were first identified. The first one was defined as the ‘drug type’ (chemotype I), because its low CBD/THC content ratio, especially due to high THC content. The second chemotype, ‘intermediate’, has both the two main cannabinoids, THC and CBD, in a content ratio close to the unity (typically ranging from 0.5 to 3.0; chemotype II), but usually with a slight prevalence of CBD; the third one, the so-called ‘fibre’, or ‘non-drug’ type (chemotype III), has mainly CBD, an amount of THC lower than 0.3%, and therefore a high CBD/THC ratio, sometimes not calculable due to undetectability of THC (de Meijer et al. 1992). It has been recently demonstrated that all the three main chemotypes can arise simply by segregation at one locus (B) within individual F2 progenies of divergent-chemotype parentals (Mandolino et al. 2003; de Meijer et al. 2003). Today a widely accepted view of the inheritance of these three chemotypes, is based upon the occurrence, at B locus, of two codominant alleles, BD and BT, responsible for the presence of CBD and THC, respectively (de Meijer et al. 2003; Mandolino 2004).
Genetics and marker-assisted selection of the chemotype in Cannabis sativa L., Daniela Pacifico, Francesca Miselli, Mirta Micheler, Andrea Carboni, Paolo Ranalli and Giuseppe Mandolino; Molecular Breeding (2006) 17: 257–268.
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