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Friday, October 25, 2019 7:51:53 AM
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Biomarkers for Immunostimulatory Monoclonal Antibodies in Combination Strategies for Melanoma and Other Tumor Types
Clinical Cancer Research
March 1, 2013
Paolo A. Ascierto,
Michael Kalos,
David A. Schaer,
Margaret K. Callahan, and
Jedd D. Wolchok
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METHOD FOR PREPARING IMMUNE CELL EXOSOME CARRYING CHIMERIC ANTIGEN RECEPTOR AND APPLICATION THEREOF
PHARCHOICE THERAPEUTICS INC
Abstract:
(EN) Provided are a method for preparing an immune cell exosome carrying CAR obtained by isolation and an application thereof. After activating a CAR immune cell by a specific antigen, the produced exosome is subjected to further analysis, isolation, purification, and enrichment to finally obtain the immune cell exosome carrying CAR. The exosome can be used to treat a disease such as cancer and a severe infectious disease.
(FR) L'invention concerne un procédé de préparation d'un exosome de cellule immunitaire contenant un CAR obtenu par isolement, ainsi qu'une application associée. Après activation d'une cellule immunitaire CAR par un antigène spécifique, l'exosome produit est soumis à une analyse, à un isolement, à une purification et à un enrichissement supplémentaires en vue d'obtenir finalement l'exosome de cellule immunitaire contenant le CAR. L'exosome peut être utilisé pour traiter une maladie telle qu'un cancer et une maladie infectieuse grave.
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2019128952
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