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Re: DewDiligence post# 225761

Wednesday, 07/31/2019 5:53:20 PM

Wednesday, July 31, 2019 5:53:20 PM

Post# of 257369
I must admit that I closed my position and (currently) do not have any companies that develop a treatment for HBV in my portfolio.

RNAi-based compounds are simpy "too effective" in bringing down HBV RNA/DNA, i.e. too strong competition. Still, I am not sure if they are the final solution - IMHO it'd be ideal to have an compound to bring down HBsAg - the decoy/distraction to the immune systeme - while allowing some low HBV activity in cells so these cells can be identified and removed (if everything is perfectly silenced, infected and healthy cells are impossible to distinguish).

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