PharmaCyte Biotech Inc (PMCB)

[DragonBear]

PMCB years behind nearest competitor-for site drug delivery

The nearest competitor for site drug delivery is

RenovoRX

They use an FDAapproved double balloon catheter Renovocath to inject gemcitabine +nab-paclitaxel, inside of a PC vein of their choosing. To be used as part of the front line induction treatment for newly diagnosed patients. In Phase 2 CTs it has yielded 22.4 month average overall survival. Overall survival for Chemo+radiation+Renovocath at 24 months 66.7%, and 5% for Chemo+radiation alone. They are now in Phase 3 (NCT03257033), involving 300 patients, and have funding.

If one wants to get excited over direct site drug injection, then there it is with RenovoRX. Shall we now make a few comparisons?

Renovocath front line treatment (larger potential patient population). CIAB second line treatment.

Renovocath delivering the front line drug therapy of gemcitabine +nab-paclitaxel, where both drugs are 100% already in the activated state. No need to encapsulate magic cells. PMCB's treatment hopes enough inactive Ifosfamide by random chance alone flows into a CIAB, and becomes activated.

Neither claims to treat metastatic PC cancer. Where 80% of newly diagnosed patients have metastasis. Although since both treatments will have drugs that go systemic, it seems the protocols in NCT03257033, will more likely control/slow down metastasis, than the Kenny wonder protocol using Metronomic Ifosfamide.

Then we have Kenny in his Kenny world of dreams, claiming PMCB will skip Phase 1, 2a which would be FDA firsts, and 6 months later, any promising results will yield breakthrough status, and an instant NDA wave into the market. Meanwhile despite very favorable results, back in the real world RenovoRX has spent years in CTs starting in Phase 1, and now in Phase 3. The Phase 3 CT started 12-Mar-2018. Expect top line results in Sep 2022. Study completion 2023.

Yes, Kenny and PMCB are years behind. The last 8 yrs of Kenny PR pumps, stumbling around not knowing what he was doing, have ensured it. So again, why is there suppose to be excitement over CIAB+Metronomic chemo treating PC, with no mythical IND submitted? Why will the whole Pharma sector come knocking on Kenny's door, IF the mythical IND ever is submitted?

Disclosure: I have no shares or affiliation with RenovoRX.