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Re: DewDiligence post# 225580

Monday, 07/15/2019 6:26:36 PM

Monday, July 15, 2019 6:26:36 PM

Post# of 252300
ABUS/AB-506 CC—Almost all of the Q&A dealt with the fact that four HBV patients (two in each dose cohort) experienced a Grade-4 ALT flare, which caused automatic discontinuation of treatment, according to the trial protocol. These flares occurred after 14 days of monotherapy treatment.

Due to these Grade-4 ALT flares seen in HBV patients, ABUS will conduct a new 28d trial in healthy volunteers to see if there are any Grade-4 ALT flares and, if so, when they occur.

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