Avid Bioservices Inc (CDMO)

[biopharm]

Yes Biocept as they required the assistance of MD Anderson for some patents of those CTCs

I wonder who Peregrine was collaborating with at that time

_____


ABSTRACT
Background: There has been increasing interest in the detection of tumor exosomes in blood for cancer diagnostics. Most studies have focused on miRNA and protein signatures that are surrogate markers for specific tumor types. Because tumor cells and tumor-derived exosomes display phosphatidylserine (PS) in their outer membrane leaflet, we developed a highly sensitive ELISA-based system that detects picogram amounts of exosomal phospholipid in plasma as a cancer biomarker.
Methods: This report describes the development of a highly specific and sensitive ELISA for the capture of PS-expressing tumor exosomes in the blood of tumor-bearing mice. To monitor the relationship between tumor burden & tumor exosome plasma concentrations, plasma from one transplantable breast cancer model (MDA-MB-231) and 3 genetic mouse models (MMTV-PyMT; breast and KIC and KPC; pancreatic) were screened for captured exosomal phospholipid.
Results: We show that quantitative assessment of PS-expressing tumor exosomes detected very early-stage malignancies before clinical evidence of disease in all 4 model systems. tumor exosome levels showed significant increases by day 7 after tumor implantation in the MDA-MB-231 model while palpable tumors appeared only after day 27. For the MMTV-PyMT and KIC models, tumor exosome levels increased significantly by day 49 (P<=0.0002) and day 21 (P<=0.001) while tumors developed only after days 60 & 40, respectively. For the KPC model, a significant increase in blood exosome levels was detected by day 70 (P=0.023) when only preinvasive lesions are microscopically detectable.
Conclusions: These data indicate that blood PS exosome levels is a specific indicator of cancer and suggest that blood PS is a biomarker for early-stage malignancies.
...Glimpse of beg. of 7pg. article:

....
....

https://investorshub.advfn.com/boards/read_msg.aspx?message_id=132443000