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Re: ghmm post# 225028

Thursday, 05/16/2019 8:45:41 PM

Thursday, May 16, 2019 8:45:41 PM

Post# of 251669
ADVM—While dose de-escalation is pretty common in a phase-1 trial (e.g. the standard "3x3" design), what we have with ADVM is unplanned de-escalation following a clinical hold. That's an altogether different story that warrants the skepticism shown in the tweets you cited.

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