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Post# of 257442
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DewDiligence

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DewDiligence

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Re: bladerunner1717 post# 224850

Monday, 05/13/2019 9:39:56 AM

Monday, May 13, 2019 9:39:56 AM

Post# of 257442
NERV -18% on purportedly positive phase-2 results in depression; the problem could be this:

https://finance.yahoo.com/news/minerva-neurosciences-announces-positive-top-121500685.html

The least squares mean (LS mean) difference from placebo of the change in MADRS total score at the end of week 6 was 3.1 for the 20 mg dose of seltorexant, and the 2-sided p-value was 0.083, which is below the pre-specified 2-sided type I error level of 0.1.

Why would the pre-specified type-1 error be as high as 0.10? Doesn’t pass the sniff test.

“The efficient-market hypothesis may be
the foremost piece of B.S. ever promulgated
in any area of human knowledge!”

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