There are several FDA-approved HBV nukes, although Viread and Vemlidy (a/k/a TAF) have made the others essentially obsolete. In a phase-3 head-to-head of Vemlidy vs Viread, both drugs reduced baseline HBV DNA by a mean value of 6-7 logs—see Table 10 (page 23) of the FDA label for Vemlidy (https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208464s007lbl.pdf ).