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$PMCB An Investigation of Enzymes Capable of Activating Cannabinoid Prodrugs PMCB

With the support from the studies reviewed in this chapter, this research aimed to isolate the phytocannabinoid cannabidiolic acid from Cannabis sativa plant material and to screen microbial cell lines which could potentially decarboxylate CBDA to CBD.

With the broad review of many different in vitro and in vivo studies citing the effects of CBD on various cancer cell lines, this natural product clearly could be the basis of a targeted cancer therapy. Cannabidiol is already an FDA-approved drug in other medicinal contexts and its high potential for other therapies could be harnessed if an appropriate manner of administration was developed. One approach involving Cell-in-aBox® begins with identifying a microbial cell line capable of enzymatic conversion of the inactive prodrug cannabidiolic acid to cannabidiol by performing cell assays on a variety of species from the literature discussed.

Ultimately, Cell-in-a-Box® technology could provide a potential mechanism of delivery for a genetically-engineered cell containing the gene necessary for an enzyme capable of catalyzing the conversion of
prodrug to active drug.

https://digscholarship.unco.edu/cgi/viewcontent.cgi?article=1128&context=theses&fbclid=IwAR0wiNSLbPjd8GucWMbR5fe42rr7G7iplI6bk4UJsIITYd_j_31w03ThJRo