SiNtx Technologies Inc (SINT)

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Current Issues and Limitations of other "Biomaterials" as compared to Silicon Nitride

How medical device harm is concealed

Everything You Need to Know About the Implant Files


Titanium

Heavy metal: Titanium implant safety under scrutiny

The Distribution and Pro-Inflammatory Impact of Titanium Debris Accumulation in the Peri-Implant Enviornment

Serum titanium, niobium, and aluminum levels after instrumented spinal arthrodesis in children.

Roughening surface of Titanium implants leads to increase corrosion and biofilm formation

Local Cellular Responses to Titanium Dioxide from Orthopedic Implants

The Potential Liver, Brain, and Embryo Toxicity of Titanium Dioxide Nanoparticles on Mice.


PEEK

Dr. Khoi Than, said, "Hundreds of thousands of PEEK implants are placed in patients' necks every year, and our work verifies my suspicion that many of them are not healing.

Pseudarthrosis following single-level ACDF is five times more likely when a PEEK interbody device is used

In the PEEK group, vertebral osteolysis was noted in 60 % of the cases with nonunion

The absence of posterior fixation in combination with lower stiffness and the hydrophobic characteristics of PEEK probably lead to insufficient initial stability, creating suboptimal conditions for bony bridging, and thus solid fusion.

PEEK Cages in Lumbar Fusion: Mid-term Clinical Outcome and Radiologic Fusion - Depuy Spacer

The similarities between periprosthetic tissue reactions in the different groups may give more insight into the clinical relevance of PE particles and inflammatory cells in the lumbar spine.

Are Periprosthetic Tissue Reactions Observed After Revision of Total Disc Replacement Comparable to the Reactions Observed After Total Hip or Knee Revision Surgery?


ZTA

ZTA phase instability when encountering metal ions

Increased wear debris due to phase instability in ZTA ceramics

Ceramic prosthesis surfaces induce an inflammatory cell response and fibrotic tissue changes

Toxic Effects of Alumina Nanoparticles in Rat Cerebrums and Kidneys

Zirconia Nanoparticles-Induced Toxic Effects in Osteoblast-Like 3T3-E1 Cells - TiO2 NP exhibited similar toxic effect

Cobalt Toxicity, An overlooked Cause of Hypothyroidism - patient with Ceramic-on-Ceramic right Hip Implant and a large amount of metal debris


Cobalt-Chromium


Stephen Tower - Wear & Corrosion of Chrome-Cobalt Hip Implants

PET Brain Imaging in Cobalt Induced Chronic Toxic Encephalopathy Associated With Chromium Cobalt Hip Implants

Investigation of metal deposition in organs after joint replacement

Metallosis after metal-on-polyethylene total hip arthroplasty

Systemic and local toxicity of metal debris released from hip prostheses: A review of experimental approaches

The Bleeding Edge: behind the terrifying new Netflix documentary


Silicon Nitride Biomaterial, the Future

List of current/potential Si3N4 based products by market application:

List of 5 human studies utilizing Silicon Nitride Spinal Implants

Reciprocity between Si3N4 and living cells

Human osteoblasts grow transitional Si/N apatite in quickly osteointegrated Si3N4 cervical insert.

Biological and therapeutic effects of ortho-silicic acid and some ortho-silicic acid-releasing compounds: New perspectives for therapy

Silicon Nitride - Antimicrobial

AMEDICA ANNOUNCES FILING OF KEY PATENT APPLICATION RELATING TO THE ANTI-VIRAL EFFECT OF ITS SILICON NITRIDE - Study has yet to be published

Development of a SiYAlON glaze for improved osteoconductivity of implantable medical devices.

Wear debris generated from SiNx coatings was round in shape, with a mean size of 40 nm, and ranged between 10 and 500 nm. Model particles, similar in size and shape as the wear debris, were soluble in simulated body fluid. The dissolution rate was higher than the expected rate of debris generation.

Dissolution behaviour of silicon nitride coatings for joint replacements

Incorporating Si3N4 into PEEK to Produce Antibacterial, Osteocondutive, and Radiolucent Spinal Implants

Bioceramics are Not Bioinert: The Role of Oxide and Non-Oxide Bioceramics on the Oxidation of UHMWPE Components in Artificial Joints


A pictures worth a thousand words


Reactions to Metals



Reaction to Silica released/scavenged from Si3N4 implant surfaces



Silicon: The evolution of its use in biomaterials