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Re: jbog post# 222616

Wednesday, 12/05/2018 2:52:47 PM

Wednesday, December 05, 2018 2:52:47 PM

Post# of 257301
<<The only thing that I didn't like in either of the press releases was that the 28 week timeline was from injection back to "baseline". I wouldn't think anyone wants to go back to "baseline" so a different metric should be implemented explaining when someone would want another injection.>>

What you want to know, Jbog, is the time to loss of none or mild wrinkle severity, which is basically when the wrinkles return and become noticeable. According to the press release,

The median time to loss of none or mild wrinkle severity was 24 weeks.



Slides 19, 20 and 22 have more detail on this, although I am a bit confused by the results in the KM curve on 22 and the response curves in 19 and 20 -- I would have though that the KM curve would basically be the inverse of the response.

https://investors.revance.com/static-files/44313e27-b5bf-46d1-a33d-7b06902860e3

The investor presentation yesterday morning went over all of the slides in a fair amount of detail. It's worth listening to, if for no other reason than to hear the Cowen analyst use the word "nuance" as a verb. He obviously is not a fan of the movie "Diner."

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