that might be my sentiment if the side effect noted was idiosyncratic with respect to the mechanism of action of the drug. but in this case the toxicology was an exaggerated state of the intended mechanism of action, namely immune stimulation. so lets hope they keep whatever caused the "extreme immune stimulation" intact but are able to control the dose/delivery/bioavailability with the new formulation to titrate the pharmacodynamic response accordingly I'm not invested in ands, but am intrigued by ana-975 and will be following it closely. hopefully it makes it back to the clinic soon