Avid Bioservices Inc (CDMO)

[goodplenty100]

Worth a mention here.

Antigen Seeding Technology (AST) Molecular Templates, Inc.

This technology may be somewhat alike as external targeting is the focus. Much like phospholipid a component of the cell membrane. When the phosphatidylserines flip to the extracellular (outer) surface of the cell, they act as a signal for macrophages.


Antigen Seeding Technology represents a novel immune-oncology approach leveraging the novel mechanism of action of Molecular Templates’ ETB technology. ETBs engineered with Antigen Seeding Technology are capable of delivering viral antigens as a payload inside the target tumor, resulting in the antigens being presented on the cell surface of the tumor cells in complex with MHC-1. ETB therapeutics incorporating antigen seeding are designed to work through dual mechanisms of action by redirecting a high avidity, pre-existing antigen-specific cytotoxic T cell (CTL) response to the tumor while at the same inducing cell death via the enzymatic and permanent destruction of ribosomes. Coupling two distinct mechanisms of tumor cell killing into one ETB molecule provides the potential to increase target penetrance, expand a prolonged immune response, and overcome tumor resistance.